Cart
sales@molnova.com
Guvacine hydrochloride
CAS No. 6027-91-4
Guvacine hydrochloride( —— )
Catalog No. M20972 CAS No. 6027-91-4
Guvacine hydrochloride is an?inhibits of GABA uptake (IC50 : 10 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | In Stock |
|
| 10MG | 50 | In Stock |
|
| 25MG | 82 | In Stock |
|
| 50MG | 120 | In Stock |
|
| 100MG | 156 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameGuvacine hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionGuvacine hydrochloride is an?inhibits of GABA uptake (IC50 : 10 μM).
-
DescriptionGuvacine hydrochloride is an?inhibits of GABA uptake (IC50 : 10 μM).
-
In VitroGuvacine hydrochloride is a potent inhibitor of GABA transporter, dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). Guvacine has low affinity at hBGT-1 (IC50 >1 mM). Guvacine hydrochloride is a potent inhibitor of GABA uptake, but does not inhibit sodium-independent GABA binding, and is weak or inactive as a GABA receptor agonist. Guvacine inhibits the uptake GABA and β-alanine with IC50s of 23 ± 2 μM, 66 ± 11 μM in the Cat spinal cord, and 8 ± 1 μM, 123 ± 28 μM in the rat cerebral cortex, respectively.
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorGABA
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number6027-91-4
-
Formula Weight163.6
-
Molecular FormulaC6H10ClNO2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?H2O : 41.67 mg/mL (254.71 mM)
-
SMILESCl.O=C(O)C1=CCCNC1
-
Chemical Name1236-Tetrahydropyridine-5-carboxylic acid hydrochloride
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Johnston G A R Krogsgaard-Larsen P Stephanson A . Betel nut constituents as inhibitors of γ-aminobutyric acid uptake[J]. Nature.
molnova catalog
related products
-
3,6-Dichlorotrimelli...
3,6-Dichlorotrimellitic acid is the key precursor that is used for preparing a variety of dichlorinated fluoresceins and rhodamines.
-
Uracil
Uracil is one of the four nucleobases in the nucleic acid of RNA can be used for drug delivery and as a pharmaceutical.
-
N-Formyl-Nle-Leu-Phe...
N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist.The derivative of this peptide is also biologically active as judged by its ability to elicit superoxide anion production by human PMNL at nanomolar concentrations.
