Guvacine hydrochloride

Research use only, not for human use.

Guvacine hydrochloride is an?inhibits of GABA uptake (IC50 : 10 μM).

Guvacine hydrochloride is an?inhibits of GABA uptake (IC50 : 10 μM).

Guvacine hydrochloride is a potent inhibitor of GABA transporter, dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). Guvacine has low affinity at hBGT-1 (IC50 >1 mM). Guvacine hydrochloride is a potent inhibitor of GABA uptake, but does not inhibit sodium-independent GABA binding, and is weak or inactive as a GABA receptor agonist. Guvacine inhibits the uptake GABA and β-alanine with IC50s of 23 ± 2 μM, 66 ± 11 μM in the Cat spinal cord, and 8 ± 1 μM, 123 ± 28 μM in the rat cerebral cortex, respectively.

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Others

Other Targets

GABA

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6027-91-4

163.6

C6H10ClNO2

>98% (HPLC)

In Vitro:?H2O : 41.67 mg/mL (254.71 mM)

Cl.O=C(O)C1=CCCNC1

1236-Tetrahydropyridine-5-carboxylic acid hydrochloride

(-20℃)

With Ice Pack

≥ 2 years